Journal article
Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese
G McColl, SA James, S Mayo, DL Howard, CG Ryan, R Kirkham, GF Moorhead, D Paterson, MD de Jonge, AI Bush
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Bioinorganic chemistry is critical to cellular function. Homeostasis of manganese (Mn), for example, is essential for life. A lack of methods for direct in situ visualization of Mn and other biological metals within intact multicellular eukaryotes limits our understanding of management of these metals. We provide the first quantitative subcellular visualization of endogenous Mn concentrations (spanning two orders of magnitude) associated with individual cells of the nematode, Caenorhabditis elegans. © 2012 McColl et al.
Related Projects (1)
Grants
Funding Acknowledgements
This work was supported by funds from the Australian Research Council and the National Health and Medical Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.