Journal article

The combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits

A Zulli, DL Hare, BF Buxton, MJ Black

ATHEROSCLEROSIS | ELSEVIER IRELAND LTD | Published : 2006

Abstract

UNLABELLED: Limited evidence suggests that myocardial fibrosis might be associated with dietary cardiovascular risk factors. OBJECTIVE: To investigate the effects of high dietary cholesterol, methionine (the precursor to homocysteine), and the combination of the two diets on myocardial fibrosis. METHODS: Rabbits were randomly allocated into four dietary groups for 12 weeks: control (Con), 1% methionine (Meth), 0.5% cholesterol (Chol) or 1% methionine plus 0.5% cholesterol (MethChol). RESULTS: Myocardial fibrosis was not significantly increased in Chol or Meth. However, interstitial fibrosis increased by 85% (p = 0.03) and perivascular fibrosis 28-fold (p < 0.01) in the MethChol group compare..

View full abstract