Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea

T Uluk; WE Allison; J Vince; H Wand; N Tefuarani; LM Causer; P Ripa; M Kariko; O Kaminiel; P Cunningham; SM Graham; JM Kaldor

Journal article

Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea

T Uluk, WE Allison, J Vince, H Wand, N Tefuarani, LM Causer, P Ripa, M Kariko, O Kaminiel, P Cunningham, SM Graham, JM Kaldor

Pediatric Infectious Disease Journal | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013

DOI: 10.1097/INF.0b013e31827412fc

Abstract

There are few data from tuberculosis (TB) endemic settings of the performance and outcome predictors of the QuantiFERON-TB Gold in Tube assay (QFT) in children with suspected TB. A prospective cross-sectional study was conducted in Papua New Guinea children with suspected TB evaluated at Port Moresby General Hospital (Port Moresby, Papua New Guinea). Two hundred sixteen children were enrolled including 106 probable TB, 87 possible TB and 23 without TB. Concordance between QFT and tuberculin skin test results was 86% (P < 0.001, κ = 0.70). QFT was significantly more likely to be positive than tuberculin skin test, overall and within the probable or possible TB categories, with no difference i..

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University of Melbourne Researchers

Stephen Graham Author

Grants

Funding Acknowledgements

This study was funded by a competitive, investigator-initiated research grant from Janssen as part of the Tibotec REACH (Research and Education in HIV/AIDS for Resource-Poor Countries) Initiative. JMK was supported by a Fellowship from Australia's National Health and Medical Research Council. The authors have no other funding or conflicts of interest to disclose.