Journal article

Haemodynamics using transthoracic echocardiography in healthy pregnant and non-pregnant baboons (Papio hamadryas)

Alicia T Dennis, Julian M Castro, Scott Heffernan, Annemarie Hennessy

Journal of Medical Primatology | WILEY | Published : 2012

Abstract

BACKGROUND: To determine systolic and diastolic function using transthoracic echocardiography in the baboon (Papio hamadryas). METHODS: Transthoracic echocardiography was performed in eight non-pregnant female and six pregnant baboons according to American Society of Echocardiography recommendations. RESULTS: Haemodynamic measurements were obtained from fourteen baboons. Compared to non-pregnant baboons, pregnant baboons demonstrated: (mean ± SD, pregnant vs. healthy) increased cardiac output (1615 ± 121 ml/minutes vs. 1317 ± 134 ml/minutes P = 0.001) due to an increased heart rate [120 ± 11 beats per minute (BPM) vs. 105 ± 6 BPM P = 0.018]. The inter-observer and intra-observer variability ..

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Grants

Funding Acknowledgements

The authors would like to acknowledge the staff at the Royal Prince Alfred Hospital Animal Care Facility and at the National Baboon Colony for their assistance with this work and Professor Colin Royse and Professor Michael Permezel for their support of this work. This work was supported by the Heart Research Institute Preeclampsia Laboratories, Sydney Australia. SonoSite Australasia Pty. Ltd. provided the TTE machine used in this study. None of the authors have a conflict of interest.