Fatal Hepatitis Mediated by Tumor Necrosis Factor TNF alpha Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
Thomas Kaufmann, Philipp J Jost, Marc Pellegrini, Hamsa Puthalakath, Raffi Gugasyan, Steve Gerondakis, Erika Cretney, Mark J Smyth, John Silke, Razq Hakem, Philippe Bouillet, Tak W Mak, Vishva M Dixit, Andreas Strasser
Immunity | CELL PRESS | Published : 2009
Awarded by NCI
Awarded by Leukemia and Lymphoma Society of America
Awarded by NATIONAL CANCER INSTITUTE
We are grateful to J. Adams, S. Cory, D. Huang, K. Rajewski, H. Koerner, and Y. Lazebnik for gifts of gene-targeted mice or antibodies. We thank K. Vella, N. lannarella, and G. Siciliano for animal care, C. Young and D. Chau for excellent technical assistance, M. Robati and B. Helbert for genotyping, the Biochemistry Department of the Royal Melbourne Hospital for ALT and AST measurements, and J. Adams, S. Cory, D. Huang, D. Vaux, and L. O'Reilly for advice and critical comments on the manuscript. This work was supported by grants (program #257502) and fellowships from the NHMRG (Canberra), the NCI (NIH, USA; #CA 80188 and #CA 43540), the Leukemia and Lymphoma Society of America (SCOR grant #7015), the JDRF/NHMRC, the Swiss National Science Foundation, the Roche Research Foundation, the Novarlis Foundation (formerly Ciba-Geigy-Jubilaeumsstiftung; postdoctoral fellowships to T.K.) and the Mildred-Scheel Stiftung/Deutsche Krebshilfe (postdoctoral fellowship to P.J.J.). V.M.D. is an employee at Genentech, Inc.