Journal article

Hop is an unusual homeobox gene that modulates cardiac development

F Chen, H Kook, R Milewski, AD Gitler, MM Lu, J Li, R Nazarian, R Schnepp, K Jen, C Biben, G Runke, JP Mackay, J Novotny, RJ Schwartz, RP Harvey, MC Mullins, JA Epstein

CELL | CELL PRESS | Published : 2002


Hop is a small, divergent homeodomain protein that lacks certain conserved residues required for DNA binding. Hop gene expression initiates early in cardiogenesis and continues in cardiomyocytes throughout embryonic and postnatal development. Genetic and biochemical data indicate that Hop functions directly downstream of Nkx2-5. Inactivation of Hop in mice by homologous recombination results in a partially penetrant embryonic lethal phenotype with severe developmental cardiac defects involving the myocardium. Inhibition of Hop activity in zebrafish embryos likewise disrupts cardiac development and results in severely impaired cardiac function. Hop physically interacts with serum response fac..

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University of Melbourne Researchers