Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins
Bernard A Callus, Donia M Moujallad, John Silke, Robert Gerl, Anissa M Jabbour, Paul G Ekert, David L Vaux
J. Mol. Biol. | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2008
Awarded by National Health and Medical Research Council
This work was supported by funds from the National Health and Medical Research Council (program grant 461221 and project grant 436936) and a Leukemia and Lymphoma Society Center grant. We thank David Huang (WEHI) for generously providing human Puma cDNA, WT and bax/bak DKO MEFs, and anti-ICAD as well as Lorraine O'Reilly for providing the anti-Bcl-2 antibody. BaF<INF>3</INF> cells were obtained from Doug Hilton (WEHI). We thank various members of D. L. Vaux's laboratory for helpful discussions. D. L. Vaux is a National Health and Medical Research Council Australia Fellow. P.G. Ekert is a Senior Medical Research Fellow of the Sylvia and Charles Viertel Charitable Foundation.