Journal article
Heritability of the spatial distribution and peak density of macular pigment: A classical twin study
RE Hogg, EL Ong, M Chamberlain, M Dirani, PN Baird, RH Guymer, F Fitzke
Eye Basingstoke | NATURE PUBLISHING GROUP | Published : 2012
DOI: 10.1038/eye.2012.98
Abstract
PurposeTo elucidate the heritability of peak density and spatial width of macular pigment (MP) using a Classical Twin Study.MethodsFundus autofluorescence images were obtained at 488 nm from 86 subjects or 43 twin pairs (21 monozygotic (MZ) and 22 dizygotic (DZ)) (27 male, 59 female) aged from 55 to 76 years (mean 62.2±5.3 years). The relative topographic distribution of MP was measured using a grey scale of intensity (0-255 units) in a 7° eccentricity around the fovea. Relative peak MP density (rPMPD) and relative spatial distribution of MP (rSDMP) were used as the main outcome measure in the statistical analysis.ResultsA significantly higher correlation was found within MZ pairs as compare..
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Awarded by Ophthalmic Research Institute of Australia
Funding Acknowledgements
We thank Dr Andrew Anderson for his help in writing the software used for the bootstrapping procedure. We thank the Australian Twin Registry for access to this national resource. This work was supported by the National Health and Medical Research Council (NHMRC) Centre for Clinical Research Excellence (#529923), NHMRC Career Development Award (RHG), and a NHMRC practitioner fellowship (RHG). This work was also supported by a grant from the Ophthalmic Research Institute of Australia. CERA receives Operational Infrastructure Support from the Victorian Government.