The presence of viral subpopulations in an infectious bronchitis virus vaccine with differing pathogenicity - A preliminary study
Kylie A Hewson, Peter C Scott, Joanne M Devlin, Jagoda Ignjatovic, Amir H Noormohammadi
Vaccine | ELSEVIER SCI LTD | Published : 2012
There are currently four commercially available vaccines in Australia to protect chickens against infectious bronchitis virus (IBV). Predominantly, IBV causes clinical signs associated with respiratory or kidney disease, which subsequently cause an increase in mortality rate. Three of the current vaccines belong to the same subgroup (subgroup 1), however, the VicS vaccine has been reported to cause an increased vaccinal reaction compared to the other subgroup 1 vaccines. Molecular anomalies detected in VicS suggested the presence of two major subspecies, VicS-v and VicS-del, present in the commercial preparation of VicS. The most notable anomaly is the absence of a 40 bp sequence in the 3'UT..View full abstract
The authors would like to acknowledge Denise O'Rourke for help isolating the subspecies and Penelope Steer and Anthony Chamings for help collecting tissue specimens. The authors would also like to thank Cheryl Colson and June Daly for overseeing the in vivo experiment. The funding for this investigation was provided by the Australian Egg Corporation Limited through a Department of Agriculture, Fisheries and Forestry 'Science and Innovation Award for Young Scientists' award.