Journal article

Serum total renin is increased before microalbuminuria in diabetes

TJ Allen, ME Cooper, RE Gilbert, J Winikoff, SL Skinner, G Jerums

KIDNEY INTERNATIONAL | BLACKWELL SCIENCE INC | Published : 1996

Abstract

Serum prorenin is increased in patients with insulin dependent diabetes mellitus (IDDM) with microvascular complications. The present longitudinal study investigated whether increases in serum total renin concentration (TRC, active+prorenin) can predict the development of microalbuminuria in IDDM patients over a 10 year period. TRC and albumin excretion rates (AER) were determined in 78 IDDM patients who were followed longitudinally for 10.4 +/- 0.2 (mean +/- SE) years. Twelve patients had progressively increasing albuminuria (progressors), and these were compared to 66 patients in whom albuminuria did not rise (non-progressors). The two groups had similar duration of diabetes, age, follow-u..

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University of Melbourne Researchers