Comparison of early renal dysfunction in type I and type II diabetes: differing associations with blood pressure and glycaemic control

Abstract

This study has investigated the relationship of glycaemic control, blood pressure and proteinuria to early renal dysfunction in a cohort of 50 type I and 65 type II diabetics, with renal function ranging from normal to mildly impaired (serum creatinine <0.2 mM). Repeated measurements were made over a mean interval of 7 years and mean data from each subject were analysed by stepwise multiple linear regression. This enabled associations to be determined independently of the confounding influence of age and duration of disease. In type I diabetics, mean creatinine clearance was inversely related to systolic blood pressure (P < 0.001), glycosylated haemoglobin (P < 0.05), fasting plasma glucose ..