Journal article

Do Helicobacter pylori therapeutic vaccines need to be tailored to the age of the recipient?

Philip Sutton, Karen Robinson

EXPERT REVIEW OF VACCINES | EXPERT REVIEWS | Published : 2012

Abstract

Helicobacter pylori infections typically commence during childhood and last for life. Freire de Melo and colleagues compared cytokine profiles in the stomachs of H. pylori-infected and H. pylori-uninfected children and adults from Brazil. They suggest that the immune effector response in infected children differs from infected adults, specifically that stomachs of infected children contained elevated regulatory T-cell markers and less IL-17 compared with adults. As vaccine-mediated protection against H. pylori is believed to involve IL-17 and to be inhibited by regulatory T cells, this raises the possibility that individual H. pylorivaccines may have different efficacies in children and adul..

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