Blockade of the renin-angiotensin system improves the early stages of liver regeneration and liver function
Shir Lin Koh, Eleanor Ager, Cathy Malcontenti-Wilson, Vijayaragavan Muralidharan, Christopher Christophi
JOURNAL OF SURGICAL RESEARCH | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2013
BACKGROUND: Partial hepatectomy is the preferred option for selected patients with colorectal cancer liver metastases (CRCLM). Sufficient liver regeneration (LR) is essential for a successful outcome in these patients. The blockade of the renin-angiotensin system (RAS) reduces the growth of several tumor types. The RAS also acts as a regulator of liver fibrosis and potentially LR. The angiotensin-converting enzyme (ACE) inhibitor, captopril, significantly inhibits the growth of CRCLM, but its effect on LR remains undefined. METHODS: After 70% of partial hepatectomy, mice were randomly assigned to control or captopril-treated groups. LR was measured by liver-to-body weight ratio on days 1, 2,..View full abstract
Related Projects (1)
The authors wish to thank Dr Theodora Fifis and Dr Patricia L.N. Costa for reviewing the manuscript, and The University of Melbourne, Australian Rotary Health and Austin Medical Research Foundation for their support.