Journal article

Low-fidelity GABA transmission within a dense excitatory network of the solitary tract nucleus

Stuart J McDougall, Michael C Andresen

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2012

Abstract

Visceral primary afferents enter the CNS at the caudal solitary tract nucleus (NTS), and activate central pathways key to autonomic and homeostatic regulation. Excitatory transmission from primary solitary tract (ST)-afferents consists of multiple contacts originating from single axons that offer a remarkably high probability of glutamate release and high safety factor for ST afferent excitation. ST afferent activation sometimes triggers polysynaptic GABAergic circuits, which feedback onto second-order NTS neurons. Although inhibitory transmission is observed at second-order neurons, much less is known about the organization and mechanisms regulating GABA transmission. Here, we used a focal ..

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Grants

Awarded by National Institutes of Health


Awarded by National Health and Medical Research Council of Australia


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This work was supported by grants from the National Institutes of Health, HL-41119 (M. C. A.), HL-105703 (M. C. A.), and National Health and Medical Research Council of Australia, Overseas Training C J Martin Fellowship no. 400405 (S. J. M.). The content is solely the responsibility of the authors, and does not necessarily represent the official views of the National Heart, Lung and Blood Institute or the NIH.