Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

VR Sutton; K Sedelies; G Dewson; ME Christensen; PI Bird; RW Johnstone; RM Kluck; JA Trapani; NJ Waterhouse

Journal article

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

VR Sutton, K Sedelies, G Dewson, ME Christensen, PI Bird, RW Johnstone, RM Kluck, JA Trapani, NJ Waterhouse

Cell Death & Disease | NATURE PUBLISHING GROUP | Published : 2012

DOI: 10.1038/cddis.2012.73

University of Melbourne Researchers

Ricky Johnstone Author The Sir Peter MacCallum Department of Oncology

Grant Dewson Author Medical Biology (W.E.H.I.)

Ruth Kluck Author Medical Biology (W.E.H.I.)

Joseph Trapani Author The Sir Peter MacCallum Department of Oncology

Grants

Awarded by NHMRC

Funding Acknowledgements

This work was supported by funding from the NHMRC (Project Grant and CDA Award to NJW, project grants #575559 and #637335 to RMK, Programme Grant to JAT, RJW and PB), the Australian Research Council (Futures fellowship to NJW), project grants from the Leukaemia Foundation Queensland and the Prostate Cancer Foundation Australia to NJW. We thank Abbot Laboratories for ABT-737, Ms Kate Whitecross, Dr. Jamie Lopez and Dr. Daniella Brasacchio for helpful technical discussions, Ms Diana Motion for editorial assistance, and Mr Kevin Thia for graphical expertise. Owing to editorial limits we were unable to cite all relevant publications.