Revisiting regulatory T cells in type 1 diabetes

Y Zhang; E Bandala-Sanchez; LC Harrison

Journal article

Revisiting regulatory T cells in type 1 diabetes

Y Zhang, E Bandala-Sanchez, LC Harrison

Current Opinion in Endocrinology Diabetes and Obesity | Published : 2012

DOI: 10.1097/MED.0b013e328355a2d5

Abstract

Purpose of review Regulatory T cells (Treg) maintain immune homeostasis and prevent autoimmune disease. This review summarizes the recent advances in Treg knowledge relevant to type 1 diabetes, focusing on Treg signature, antigen specificity and development and function in the face of inflammation. Recent findings Thymus-derived natural regulatory T cells (nTreg) programmed by the transcription factor forkhead box P3 (FOXP3) and peripheral-induced regulatory T cells (iTreg) have largely nonoverlapping T-cell receptor repertoires to self-antigens and jointly contribute to immune homeostasis. Initial reports that CD4CD25 (FOXP3) Treg were impaired in frequency or function in type 1 diabetes ha..

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University of Melbourne Researchers

Maria Bandala Sanchez Author

Leonard Harrison Author

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This work was supported by a Program Grant (305500) from the National Health and Medical Research Council of Australia (NHMRC) (to L. C. H.) and by a Victorian State Government Operational Infrastructure Support Grant. Y.Z. is a Juvenile Diabetes Research Foundation Postdoctoral Fellow and L. C. H. a Senior Principal Research Fellow of the NHMRC.