Journal article
Teratogenesis in repeated pregnancies in antiepileptic drug-treated women
FJE Vajda, TJ O'Brien, CM Lander, J Graham, A Roten, MJ Eadie
Epilepsia | Published : 2013
Abstract
Purpose: Considerable information is now available concerning the risk of teratogenesis in the individual pregnancy exposed to antiepileptic drugs (AEDs). However, there is comparatively little information available concerning the risk in the subsequent pregnancies of women who continue to take the AED associated with a fetal malformation in a previous pregnancy. This article addresses this matter. Methods: Analysis of data concerning fetal abnormalities in 1,243 women who had 2,637 pregnancies between mid-1999 and 2010 recorded in the Australian Register of Antiepileptic Drugs in Pregnancy. Of the 2,637 pregnancies, 1,114 had been completed before initial enrolment in the Register. Key Find..
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Funding Acknowledgements
We wish to acknowledge the help of our medical and nonmedical colleagues, both in referring patients and in increasing patient awareness of the Register. We thank the Scientific Advisory Board and the Ethical Research Committees of St. Vincent's Hospital, Monash Medical Centre, the Royal Melbourne Hospital, and other institutions for their ethics assessments of the study. The Australian Register is grateful for support from the Epilepsy Society of Australia, Royal Melbourne Hospital Neuroscience Foundation, The Victorian Epilepsy Foundation, Epilepsy Australia, National Health and Medical Research Council linkage grant, and also for financial support from a number of pharmaceutical companies, including Sanofi-Aventis, UCB Pharma, Janssen-Cilag, Novartis, Sci-Gen, and Pfizer, as well as for past support from Glaxo.