Journal article
Community-acquired neonatal and infant sepsis in developing countries: Efficacy of WHO's currently recommended antibiotics-systematic review and meta-analysis
L Downie, R Armiento, R Subhi, J Kelly, T Duke, V Clifford
Archives of Disease in Childhood | Published : 2012
Abstract
Objective: To review the aetiology and antibiotic resistance patterns of community-acquired sepsis in developing countries in infants where no clear focus of infection is clinically identified. To estimate the likely efficacy of WHO's recommended treatment for infant sepsis. Design: A systematic review of the literature describing the aetiology of community-acquired neonatal and infant sepsis in developing countries. Using meta-analytical methods, susceptibility was determined to the antibiotic combinations recommended by WHO: (1) benzylpenicillin/ampicillin and gentamicin, (2) chloramphenicol and benzylpenicillin, and (3) third-generation cephalosporins. Results: 19 studies were identified ..
View full abstractGrants
Funding Acknowledgements
This research was supported by funding from the AusAID Knowledge Hubs for Health Initiative given to the Centre for International Child Health (CICH), The University of Melbourne. CICH is also a World Health Organization Collaborating Centre for Research and Training in Child and Neonatal Health. Neither agency influenced the publication of these results.