Journal article
Diffuse ventricular fibrosis in atrial fibrillation: Noninvasive evaluation and relationships with aging and systolic dysfunction
LH Ling, PM Kistler, AH Ellims, LM Iles, G Lee, GL Hughes, JM Kalman, DM Kaye, AJ Taylor
Journal of the American College of Cardiology | ELSEVIER SCIENCE INC | Published : 2012
Abstract
Objectives: The purpose of this study was to evaluate diffuse myocardial fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF). Background: Diffuse myocardial fibrosis is a hallmark of cardiomyopathy. Unlike replacement fibrosis, it is not visualized on delayed-enhancement cardiac magnetic resonance (CMR) imaging, but may be quantified with contrast-enhanced T1 mapping methods. In atrial fibrillation (AF), it may be induced by arrhythmia or reflect pre-existing cardiomyopathy. Methods: Ninety subjects underwent CMR using a clinical 1.5-T scanner: 23 controls, 40 paroxysmal AF patients, and 27 persistent AF patients. Cardiac morphology and function was evaluated from C..
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Funding Acknowledgements
Dr. Ling is supported by an Australian National Heart Foundation (NHF) postgraduate scholarship. Dr. Kistler is the recipient of a research investigatorship from the Cardiac Society of Australia and New Zealand. Dr. Ellims holds a cofunded Australian National Health and Medical Council (NHMRC)/NHF postgraduate scholarship. Dr. Iles is supported by an NHMRC postgraduate research scholarship. Dr. Kaye is supported by an NHMRC program grant. Dr Taylor is supported by an NHMRC program grant and an NHF project grant. This research is supported in part by the Victorian Government's Operational Infrastructure Funding. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.