Determination of protein subcellular localization in apicomplexan parasites
Ben J Woodcroft, Paul J McMillan, Chaitali Dekiwadia, Leann Tilley, Stuart A Ralph
TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2012
Parasites from the phylum Apicomplexa include causative agents of serious diseases including malaria (Plasmodium spp.) and toxoplasmosis (Toxoplasma gondii). Apicomplexan parasites infect thousands of types of animal cells and send their proteins to an array of compartments within their own cell, as well as exporting proteins into and beyond their host cell. Ascertaining destinations to which individual proteins are delivered allows researchers to better understand parasite biology and to identify potential targets for therapeutic interventions. Our toolkit for establishing subcellular locations of apicomplexan proteins is becoming more extensive and specialized, and here we review developme..View full abstract
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Awarded by Australian Research Council
We thank Dr Cheryl Chia and Dr Martin Blume (University of Melbourne) for helpful discussions. S.A.R. is supported by an Australian Research Council Future fellowship (FT0990350). B.J.W. is supported by a Melbourne Research Scholarship.