Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

Jo-Anne Chan; Katherine B Howell; Linda Reiling; Ricardo Ataide; Claire L Mackintosh; Freya JI Fowkes; Michaela Petter; Joanne M Chesson; Christine Langer; George M Warimwe; Michael F Duffy; Stephen J Rogerson; Peter C Bull; Alan F Cowman; Kevin Marsh; James G Beeson

Journal article

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

Jo-Anne Chan, Katherine B Howell, Linda Reiling, Ricardo Ataide, Claire L Mackintosh, Freya JI Fowkes, Michaela Petter, Joanne M Chesson, Christine Langer, George M Warimwe, Michael F Duffy, Stephen J Rogerson, Peter C Bull, Alan F Cowman, Kevin Marsh, James G Beeson

JOURNAL OF CLINICAL INVESTIGATION | AMER SOC CLINICAL INVESTIGATION INC | Published : 2012

DOI: 10.1172/JCI62182

Download PDF

University of Melbourne Researchers

Alan Cowman Author Medical Biology (W.E.H.I.)

Freya Fowkes Author Melbourne School of Population and Global Health

Michael Duffy Author Microbiology and Immunology

Stephen Rogerson Author Medicine - Royal Melbourne Hospital

Michaela Petter Author Medicine - Royal Melbourne Hospital

Related Projects (2)

Surface Antigens Aof Plasmodium Falciparum-Infected Erythocytes And Immunity To Malaria In Humans

Malaria is a leading cause of death globally, particularly among children. Malaria parasites infect red blood cells and multiply inside them..

Defining The Targets And Function Of Antibodies That Protect Against Malaria In Pregnancy

Malaria during pregnancy is a major cause of maternal and infant morbidity and mortality globally. In this project we aim to define the targ..

Grants

Awarded by Fundacao para a Ciencia e a Tecnologia from Portugal

Funding Acknowledgements

Thanks to all participants in the study; Moses Mosobo, Brett Lowe, Tabitha Mwangi, and staff at the Kenya Medical Research Institute for technical assistance; and Gaogian Feng for help with phagocytosis assays. Funding was provided by the National Health and Medical Research Council of Australia (project grant and career development award to J. Beeson; training award to F. Fowkes; Australian postgraduate award to J. Chan; Infrastructure for Research Institutes Support Scheme Grant), Australian Research Council (Future Fellowship to J. Beeson), the Welcome Trust, United Kingdom, and the Victorian State Government Operational Infrastructure Support grant. R. Ataide was supported by the Fundacao para a Ciencia e a Tecnologia from Portugal (fellowship number SFRH/BD/32985/2006). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This paper is submitted with the permission of the director of the Kenya Medical Research Institute.