Journal article
Volumetric MRI Markers and Predictors of Disease Activity in Early Multiple Sclerosis: A Longitudinal Cohort Study
T Kalincik, M Vaneckova, M Tyblova, J Krasensky, Z Seidl, E Havrdova, D Horakova
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Open access
Abstract
Objectives: To compare clinical and MRI parameters between patients with clinically isolated syndrome and those converting to clinically definite multiple sclerosis within 2 years, to identify volumetric MRI predictors of this conversion and to assess effect of early relapses. Methods: The SET study comprised 220 patients with clinically isolated syndrome treated with interferon beta (mean age, 29 years; Expanded Disability Status Scale, 1.5). Three patients with missing data were excluded from the analysis. Physical disability, time to clinically definite multiple sclerosis and volumetric MRI data were recorded for 2 years. Results: Patients reaching clinically definite multiple sclerosis s..
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Awarded by Czech Ministries of Education and Health
Funding Acknowledgements
The study was supported by Czech Ministries of Education and Health [NT13237-4/2012, MSM 0021620849, PRVOUK-P26/LF1/4, RVO-VFN64165/2012] and Biogen Idec (http://www.biogenidec.com/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.The authors have read the journal's policy and have the following conflicts: TK received compensation for travel and honoraria from Biogen Idec, Sanofi Aventis, Teva and Merck Serono. MV received compensation for travel and honoraria from Biogen Idec. MT received compensation for travel and honoraria from Biogen Idec, Sanofi Aventis, Teva and Merck Serono. JK received compensation for travel and honoraria from Biogen Idec and Sanofi Aventis. ZS received compensation for travel and honoraria from Biogen Idec. EH received speaker honoraria and consultant fees from Biogen Idec, Merck Serono, Novartis, Genzyme and Teva, as well as support for research activities from Biogen Idec and Merck Serono. DH received speaker honoraria and consultant fees from Biogen Idec, Novartis, Merck Serono and Bayer Shering, as well as support for research activities from Biogen Idec. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.