Journal article
Altered functional brain connectivity in a non-clinical sample of young adults with attention-deficit/hyperactivity disorder
L Cocchi, IE Bramati, A Zalesky, E Furukawa, LF Fontenelle, J Moll, G Tripp, P Mattos
Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2012
Abstract
Attention-deficit/hyperactivity disorder(ADHD)is characterized by symptoms of in attention and hyperactivity/impulsivity that often persist in adulthood. There is a growing consensus that ADHD is associated with abnormal function of diffuse brain networks, but such alterations remain poorly characterized. Using resting-state functional magnetic resonance imaging, we characterized multivariate (complex network measures), bivariate (network-based statistic), and univariate (regional homogeneity) properties of brain networks in a non-clinical, drug-naive sample of high-functioning young men and women with ADHD (nine males, seven females) and a group of matched healthy controls. Data from our sa..
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Awarded by Australian Research Council
Awarded by Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Funding Acknowledgements
This study was supported by a joint research agreement between OIST and IDOR. L.C. was supported by the National and International Research Alliance Program from the Queensland Government (Australia). A.Z. is grateful for the support provided by Prof. Trevor Kilpatrick as part of the inaugural Melbourne Neuroscience Institute Fellowship. This work was also supported by the Australian Research Council Grant DP0986320 (to A.Z.). L.F.F., P.M., I.E.B., and J.M. were supported by D'Or Institute for Research and Education Grants. L.F.F. was supported by Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) Awards ID E-26/111.176/2011 and E-26/103.252/2011 and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Award (303846/2008-9). We thank Prof. Jason B. Mattingley and Dr. Natasha Matthews for providing important scientific input to the initial drafts of this manuscript. Dr. Cocchi had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.