Journal article

B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent Rel/NF-kappa B regulated induction of c-myc transcription

RJ Grumont, A Strasser, S Gerondakis

MOLECULAR CELL | CELL PRESS | Published : 2002


Rel/NF-kappaB transcription factors regulate the division and survival of B lymphocytes. Here we show that B cells lacking NF-kappaB1 and c-Rel fail to increase in size upon mitogenic stimulation due to a reduction in induced c-myc expression. Mitogen-induced B cell growth, although not markedly impaired by FRAP/mTOR or MEK inhibitors, required phosphatidylinositol 3-kinase (PI3K) activity. Inhibition of PI3K-dependent growth coincided with a block in the nuclear import of NF-kappaB1/c-Rel dimers and a failure to upregulate c-myc. In addition, PI3K was shown to be necessary for a transcription-independent increase in c-Myc protein levels that accompanies mitogenic activation. Collectively, t..

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University of Melbourne Researchers