Journal article

Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites

M Kalkanidis, N Klonis, S Tschan, LW Deady, L Tilley

BIOCHEMICAL PHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2004

Abstract

We have previously shown that structural modification of chlorpromazine to introduce a basic side chain converts this chloroquine (CQ) resistance-reversing agent into a compound that has activity against Plasmodium falciparum in vitro. In an effort to further dissect the structural features that determine quinoline antimalarial activity and drug resistance-reversing activity, we have studied a series of aminoquinolines that are structurally related to CQ. We have analysed their haematin-binding activities, their antimalarial activities and their abilities to synergise the effect of CQ against drug-resistant P. falciparum. We found that a number of the aminoquinolines were able to interact wi..

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University of Melbourne Researchers