Journal article

Mass spectrometric analysis of gingival crevicular fluid biomarkers can predict periodontal disease progression

LH Ngo, IB Darby, PD Veith, AG Locke, EC Reynolds



BACKGROUND AND OBJECTIVE: Gingival crevicular fluid has been suggested as a possible source of biomarkers for periodontal disease progression. This paper describes a technique for the analysis of gingival crevicular fluid from individual sites using mass spectrometry. It explores the novel use of mass spectrometry to examine the relationship between the relative amounts of proteins and peptides in gingival crevicular fluid and their relationship with clinical indices and periodontal attachment loss in periodontal maintenance patients. The aim of this paper was to assess whether the mass spectrometric analysis of gingival crevicular fluid may allow for the site-specific prediction of periodon..

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Funding Acknowledgements

The authors wish to thank Dental Health Services Victoria for providing a source of patients for gingival crevicular fluid sample collection. The authors would like to acknowledge the help of Dr S. Byrne for her clinical assistance. This work was funded by the National Health and Medical Research Council, the Australian Dental Research Foundation, and the Collaborative Research Centre for Oral Health Sciences, Melbourne Dental School, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, Australia. This work formed part of the PhD thesis of Luan Ngo.