Validation of an echocardiographic assessment of cardiac function following moderate size myocardial infarction in the rat

Abstract

1. The present study determined whether two dimensional guided M-mode echocardiography could assess left ventricular (LV) geometry and function following a moderate size myocardial infarction in the rat. 2. Myocardial infarction (MI) was induced by left coronary artery ligation and rats were studied 4 weeks later. Infarct rats showed increased LV internal diastolic diameter (7.33 ± 0.8 vs 5.91 ± 0.6 mm; P<0.001), LV systolic diameter (3.73 ± 1.2 vs 1.87 ± 0.6 mm; P < 0.001) and thickening of the noninfarcted posterior wall compared with sham operated rats (1.81 ± 0.2 vs 1.47 ± 0.3; P<0.001; n = 10/group; mean ± s.d.). Systolic function was impaired in infarct rats who showed reduced fraction..