Journal article
Plasma retinol: A novel marker for cardiovascular disease mortality in Australian adults
L Brazionis, KZ Walker, C Itsiopoulos, K O'Dea
Nutrition Metabolism and Cardiovascular Diseases | Published : 2012
Abstract
Background and aims: Vitamin A affects inflammation and immune function and is thus a factor of interest in relation to cardiovascular disease (CVD). As vitamin A circulates in the plasma in the form of retinol, this study aims to describe the relationship between plasma retinol and the 5-year incidence of CVD mortality. Methods and results: Community-dwelling adults (n = 441, 45% with type 2 diabetes) were recruited in Melbourne, assessed at baseline and followed for 5 years. At baseline, CVD risk factors were assessed by clinical evaluation, by personal lifestyle questionnaire and from biochemistry (plasma fasting glucose, lipids, total homocysteine, C-reactive protein, retinol and caroten..
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Awarded by University of Melbourne
Funding Acknowledgements
This work would not have been possible without the Melbourne Collaborative Cohort Study and the infrastructure support provided by the Cancer Council Victoria. The authors would also like to acknowledge Connie Karschimkus for supervision of and assistance with laboratory analyses, and Dr Sue Qing for analysis of plasma antioxidants, including retinol. The study was supported by funds from the National Health and Medical Research Council of Australia (Project Grant124317) and the Clinical Centre for Research Excellence in Clinical Science in Diabetes, University of Melbourne. The authors declare no conflict of interest.