Androgens, diabetes and prostate cancer
Mathis Grossmann, Gary Wittert
ENDOCRINE-RELATED CANCER | BIOSCIENTIFICA LTD | Published : 2012
Metabolic disorders such as diabetes, obesity and the metabolic syndrome have been shown to modulate prostate cancer (PCa) risk and aggressiveness in population-based and experimental studies. While associations between these conditions are modest and complex, two consistent findings have emerged. First, there is observational evidence that obesity and associated insulin excess are linked to increased PCa aggressiveness and worse outcomes. Secondly and somewhat paradoxically, long-standing diabetes may be protective against PCa development. This apparent paradox may be due to the fact that long-standing diabetes is associated with insulin depletion and decreased IGF1 signalling. Men with obe..View full abstract
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Awarded by National Health and Medical Research Council of Australia
M Grossmann was supported by grants from the National Health and Medical Research Council of Australia (grant numbers 1006407, 1024139).