The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury
Veena Roberts, Bo Lu, Siddharth Rajakumar, Peter J Cowan, Karen M Dwyer
PURINERGIC SIGNALLING | SPRINGER | Published : 2013
Hypoxic injury occurs when the blood supply to an organ is interrupted; subsequent reperfusion halts ongoing ischemic damage but paradoxically leads to further inflammation. Together this is termed ischemia-reperfusion injury (IRI). IRI is inherent to organ transplantation and impacts both the short- and long-term outcomes of the transplanted organ. Activation of the purinergic signalling pathway is intrinsic to the pathogenesis of, and endogenous response to IRI. Therapies targeting the purinergic pathway in IRI are an attractive avenue for the improvement of transplant outcomes and the basis of ongoing research. This review aims to examine the role of adenosine receptor signalling and the ..View full abstract
Veena Roberts and Siddharth Rajakumar are supported by Kidney Health Australia, and Karen Dwyer is funded by Perpetual Philanthropic Services.