Journal article

Local cell traffic and cytokine production associated with ectoparasite infection

AD Nash, PJ Egan, W Kimpton, MJ Elhay, VM Bowles

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | ELSEVIER | Published : 1996

Abstract

This paper reviews recent advances in our understanding of changes in local cellular traffic and cytokine synthesis that occur as a result of infection of sheep with the ectoparasite Lucilia cuprina. Changes in the cellular composition and cytokine profile of infected skin and draining afferent and efferent lymph were assessed using standard approaches and, in addition, a variety of techniques that have only recently become available as a result of advances in ruminant cytokine biology. These include cytokine-specific immunoassay, reverse transcription PCR (RT-PCR) and immunohistology. The initial acute inflammatory response was characterised by the infiltration of polymorphonuclear cells fo..

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