Journal article

Intraocular Pressure-lowering Efficacy of Brinzolamide When Added to Travoprost/Timolol Fixed Combination as Adjunctive Therapy

Ivan Goldberg, Jonathan G Crowston, Mark C Jasek, Jeanette A Stewart, William C Stewart



PURPOSE: To compare the efficacy of brinzolamide versus placebo when added to travoprost/timolol fixed combination (TTFC) in uncontrolled patients. PATIENTS AND METHODS: This was a prospective, double-masked, randomized, placebo-controlled, parallel comparison of ocular hypertensive or primary open-angle glaucoma patients. Patients treated with a prostaglandin-based mono or adjunctive therapy were changed to TTFC qam (every day dosing) for 4 weeks. Patients with an intraocular pressure (IOP) of 19 to 32 mm Hg at 08:00 hours underwent additional measurements at 12:00 and 16:00 hours. Patients were then randomized to either placebo or brinzolamide given twice daily in addition to TTFC. At week..

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Funding Acknowledgements

This clinical trial received an unrestricted grant from Alcon Laboratories, Inc, Fort Worth, TX. The sponsor participated in the design of the study and review of the manuscript.I. Goldberg, Alcon Laboratories: consultant/Advisory Board Member (C), Lecture Fees (L), Study Support (S). Allergan: C, L, S. Merck: C. Pfizer: C, S. J. G. Crowston, site received an unrestricted research funding from Alcon; M. C. Jasek, an Alcon employee, but no conflict; J. A. Stewart and W. C. Stewart, trial received an unrestricted grant from Alcon, but report no conflict.