Journal article

MEK/ERK-Mediated Phosphorylation of Bim Is Required to Ensure Survival of T and B Lymphocytes during Mitogenic Stimulation

Lorraine A O'Reilly, Elizabeth A Kruse, Hamsa Puthalakath, Priscilla N Kelly, Thomas Kaufmann, David CS Huang, Andreas Strasser

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2009

DOI: 10.4049/jimmunol.0803853

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Awarded by NATIONAL CANCER INSTITUTE

Awarded by NCI NIH HHS

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Keywords

Bcl-2-Like Protein 11
Apoptosis Regulatory Proteins
Mice
Mice, Inbred C57bl
Lymphoid-Cells
Proto-Oncogene Proteins
Lymphocyte Activation
Tetradecanoylphorbol Acetate
Science & Technology
Immune-System
T-Lymphocyte Subsets
Rats
Bcl-2 Family
Kinase Pathway
Immunology
Ionomycin
Life Sciences & Biomedicine
Family-Member Bim
Immunoglobulin Fab Fragments
Induced Apoptosis
Signaling Pathway
Cell Survival
Cell-Survival
Animals
Membrane Proteins
In-Vivo
B-Lymphocyte Subsets
Mice, Knockout
Mice, Transgenic
Bh3-Only Protein Bim
Extracellular Signal-Regulated Map Kinases
Phosphorylation
Mitogen-Activated Protein Kinases
Cells, Cultured
Rats, Wistar
Mitogens