Journal article
Substitution monotherapy with levetiracetam vs older antiepileptic drugs: A randomized comparative trial
T Hakami, M Todaro, S Petrovski, L MacGregor, D Velakoulis, M Tan, Z Matkovic, A Gorelik, D Liew, R Yerra, TJ O'Brien
Archives of Neurology | Published : 2012
Abstract
Objective: To determine whether patients who fail their first antiepileptic drug (AED) have better neuropsychiatric and quality-of-life (QOL) outcomes if substituted to levetiracetam monotherapy compared with a second older AED. Design: Randomized comparative trial. Participants with partial epilepsy who had failed monotherapy with phenytoin sodium, carbamazepine, or valproate sodium were randomized to substitution monotherapy with levetiracetam or a different older AED. Assessments were performed at baseline, 3 months, and 12 months using questionnaires measuring neuropsychiatric, QOL, seizure control,AED adverse effects, and neurocognitive outcomes. Setting: Epilepsy service of a teaching ..
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Funding Acknowledgements
[ "Dr MacGregor has received research support from CSL, Amrad, Biogen Idec, and Prana and is currently an employee of Roche. Dr O'Brien has received research support from UCB Pharma, Sanofi, Janssen-Cilag, and Novartis as well as competitive grant support from the National Health and Medical Research Council and the Royal Melbourne Hospital Research Foundation.", "This was an investigator-initiated study partly funded by UCB Pharma as well as the Royal Melbourne Hospital Neuroscience Foundation. Dr Hakami was supported by a PhD scholarship from Jazan University, Jazan, Saudi Arabia." ]