Journal article

Genome-wide association study of glioma and meta-analysis

Preetha Rajaraman, Beatrice S Melin, Zhaoming Wang, Roberta McKean-Cowdin, Dominique S Michaud, Sophia S Wang, Melissa Bondy, Richard Houlston, Robert B Jenkins, Margaret Wrensch, Meredith Yeager, Anders Ahlbom, Demetrius Albanes, Ulrika Andersson, Laura E Beane Freeman, Julie E Buring, Mary Ann Butler, Melissa Braganza, Tania Carreon, Maria Feychting Show all

HUMAN GENETICS | SPRINGER | Published : 2012

Abstract

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and..

View full abstract

Grants

Awarded by NCI, NIH


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

This research was supported by intramural funds from the NCI, NIH, Department of Health and Human Services, and has been funded in whole or in part with federal funds from the NCI, NIH, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US government. We are indebted to the scientific and field efforts of Michelle Brotzman (Westat), Laurie Burdette, Peter Hui (IMS), Annelie Landgren, Leah Mechanic, Lisa Newman (RTI), Aurelie Vogt, Tim Sheehy, Mitchel Berger, Susan Chang, Mike Prados, Tarik Tihan, Ivan Smirnov, and Lucie McCoy.