Genome-wide association study identifies three new melanoma susceptibility loci

JH Barrett; MM Iles; M Harland; JC Taylor; JF Aitken; PA Andresen; LA Akslen; BK Armstrong; MF Avril; E Azizi; B Bakker; W Bergman; G Bianchi-Scarrà; B Bressac-De Paillerets; D Calista; LA Cannon-Albright; E Corda; AE Cust; T Dȩbniak; D Duffy; AM Dunning; DF Easton; E Friedman; P Galan; P Ghiorzo; GG Giles; J Hansson; M Hocevar; V Höiom; JL Hopper; C Ingvar; B Janssen; MA Jenkins; G Jönsson; RF Kefford; G Landi; MT Landi; J Lang; J Lubiński; R MacKie; J Malvehy; NG Martin; A Molven; GW Montgomery; FA Van Nieuwpoort; S Novakovic; H Olsson; L Pastorino; S Puig; JA Puig-Butille; J Randerson-Moor; H Snowden; R Tuominen; P Van Belle; N Van Der Stoep; DC Whiteman; D Zelenika; J Han; S Fang; JE Lee; Q Wei; GM Lathrop; EM Gillanders; KM Brown; AM Goldstein; PA Kanetsky; GJ Mann; S MacGregor; DE Elder; CI Amos; NK Hayward; NA Gruis; F Demenais; JAN Bishop; DT Bishop

Journal article

Genome-wide association study identifies three new melanoma susceptibility loci

JH Barrett, MM Iles, M Harland, JC Taylor, JF Aitken, PA Andresen, LA Akslen, BK Armstrong, MF Avril, E Azizi, B Bakker, W Bergman, G Bianchi-Scarrà, B Bressac-De Paillerets, D Calista, LA Cannon-Albright, E Corda, AE Cust, T Dȩbniak, D Duffy Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2011

DOI: 10.1038/ng.959

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Abstract

We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10 -5 and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication ca..

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University of Melbourne Researchers

Mark Jenkins Author

Grants

Awarded by Melanoma Research Alliance

Funding Acknowledgements

This study makes use of data generated by the Wellcome Trust Case Control Consortium. A full list of the investigators who contributed to the generation of the data is available from their website (see URLs). Funding for the project was provided by the Wellcome Trust under award 076113. The GenoMEL study was funded by the European Commission under the 6<SUP>th</SUP> Framework Programme (contract no. LSHC-CT-2006-018702), by Cancer Research UK Programme Awards (C588/A4994 and C588/A10589), by a Cancer Research UK Project grant (C8216/A6129) and by a grant from the US National Institutes of Health (NIH; CA83115). This research was also supported by the Intramural Research Program of the NIH, National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics. Funding specific to particular locations is acknowledged below.