Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer: Trans-Tasman Radiation Oncology Group Trial 01.04
Samuel Y Ngan, Bryan Burmeister, Richard J Fisher, Michael Solomon, David Goldstein, David Joseph, Stephen P Ackland, David Schache, Bev McClure, Sue-Anne McLachlan, Joseph McKendrick, Trevor Leong, Cris Hartopeanu, John Zalcberg, John Mackay
JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2012
PURPOSE: To compare the local recurrence (LR) rate between short-course (SC) and long-course (LC) neoadjuvant radiotherapy for rectal cancer. PATIENTS AND METHODS: Eligible patients had ultrasound- or magnetic resonance imaging-staged T3N0-2M0 rectal adenocarcinoma within 12 cm from anal verge. SC consisted of pelvic radiotherapy 5 × 5 Gy in 1 week, early surgery, and six courses of adjuvant chemotherapy. LC was 50.4 Gy, 1.8 Gy/fraction, in 5.5 weeks, with continuous infusional fluorouracil 225 mg/m(2) per day, surgery in 4 to 6 weeks, and four courses of chemotherapy. RESULTS: Three hundred twenty-six patients were randomly assigned; 163 patients to SC and 163 to LC. Median potential follow..View full abstract
Awarded by National Health and Medical Research Council
Supported by Grant No. 209123 from the National Health and Medical Research Council, Cancer Council Victoria, and the Royal Australian and New Zealand College of Radiologists.