Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer
John Mills, Alice Oliver, Justin C Sherwin, Mark Frydenberg, Justin S Peters, Anthony Costello, Laurence Harewood, Christopher Love, Nicholas Redgrave, Kenneth L van Golen, Michael Bailey, John Pedersen
PATHOLOGY | ELSEVIER SCIENCE BV | Published : 2012
AIMS: To assess the prognostic utility of semi-quantiative expression of RhoC protein in whole prostates from patients who had radical prostatectomies for high grade prostate cancer (PCa). METHODS: Subjects who had surgery >55 months previously with primary Gleason pattern 4 PCa were identified from practice records, archival tissues were retrieved for review and RhoC immunohistochemistry, and ZAG expression was also assessed as a control. RESULTS: Eighty-nine subjects were included in the study; 57 had a rising prostate specific antigen (PSA) post-operatively ('cases') and 32 did not ('controls'). By univariate analysis, expression of both RhoC and ZAG proteins was greater in controls than ..View full abstract
This project was supported by research funds from TissuPath and by a generous grant from the Prostate Cancer Foundation of Australia. The authors state that there are no conflicts of interest to disclose.