Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate-risk disease

NM Corcoran; CM Hovens; C Metcalfe; MKH Hong; J Pedersen; RG Casey; J Peters; L Harewood; SL Goldenberg; AJ Costello; ME Gleave

Journal article

Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate-risk disease

NM Corcoran, CM Hovens, C Metcalfe, MKH Hong, J Pedersen, RG Casey, J Peters, L Harewood, SL Goldenberg, AJ Costello, ME Gleave

BJU International | Published : 2012

DOI: 10.1111/j.1464-410X.2011.10868.x

Abstract

Objective To determine the impact of surgical margin status on the risk of significant biochemical recurrence (prostate-specific antigen [PSA] doubling time <3, <6 or <9 months) after prostatectomy. Materials and Methods Patients undergoing radical prostatectomy with complete clinical and pathological data and detailed PSA follow-up were identified from two prospectively recorded databases. Patients were stratified according to their risk of occult systemic disease (low risk: PSA 20 ng/dL or pT3-4 stage or Gleason score 8-10) and the impact of a positive surgical margin (PSM) within each stratum determined by univariable and multivariable analysis. Results Of 1514 patients identified, 276 (..

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University of Melbourne Researchers

Niall Corcoran Author

Christopher Hovens Author

Anthony Costello Author

Grants

Funding Acknowledgements

N.M.C. is the recipient of the Hugh Johnston Travelling Fellowship from the Royal Australasian College of Surgeons, as well as a Urological Society of Australia and New Zealand travel grant.