Journal article
Clonality Despite Sex: The Evolution of Host-Associated Sexual Neighborhoods in the Pathogenic Fungus Penicillium marneffei
DA Henk, R Shahar-Golan, KR Devi, KJ Boyce, N Zhan, ND Fedorova, WC Nierman, PR Hsueh, KY Yuen, TPM Sieu, N Van Kinh, H Wertheim, SG Baker, JN Day, N Vanittanakom, EM Bignell, A Andrianopoulos, MC Fisher
Plos Pathogens | Published : 2012
Abstract
Molecular genetic approaches typically detect recombination in microbes regardless of assumed asexuality. However, genetic data have shown the AIDS-associated pathogen Penicillium marneffei to have extensive spatial genetic structure at local and regional scales, and although there has been some genetic evidence that a sexual cycle is possible, this haploid fungus is thought to be genetically, as well as morphologically, asexual in nature because of its highly clonal population structure. Here we use comparative genomics, experimental mixed-genotype infections, and population genetic data to elucidate the role of recombination in natural populations of P. marneffei. Genome wide comparisons r..
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Awarded by Medical Research Council
Funding Acknowledgements
Primarily funding for this project comes from Wellcome Trust (084616/A/08/Z), but additional funding supported various aspects of the work and sources for this project include: Commonwealth Scholarship Commission, Research Fund for the Control of Infectious Diseases (Hong Kong), National Research University Project of Thailand's Office of the Higher Education Commission, NIAID/NIH USA, National Health and Medical Research Council of Australia, and additional funding from the Wellcome Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.