Journal article
Evaluation of tuberculosis diagnostics in children: 2. Methodological issues for conducting and reporting research evaluations of tuberculosis diagnostics for intrathoracic tuberculosis in children. Consensus from an expert panel
LE Cuevas, R Browning, P Bossuyt, M Casenghi, MF Cotton, AT Cruz, LE Dodd, F Drobniewski, M Gale, SM Graham, M Grzemska, N Heinrich, AC Hesseling, R Huebner, P Jean-Philippe, SK Kabra, B Kampmann, D Lewinsohn, M Li, C Lienhardt Show all
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2012
Abstract
Confirming the diagnosis of childhood tuberculosis is a major challenge. However, research on childhood tuberculosis as it relates to better diagnostics is often neglected because of technical difficulties, such as the slow growth in culture, the difficulty of obtaining specimens, and the diverse and relatively nonspecific clinical presentation of tuberculosis in this age group. Researchers often use individually designed criteria for enrollment, diagnostic classifications, and reference standards, thereby hindering the interpretation and comparability of their findings. The development of standardized research approaches and definitions is therefore needed to strengthen the evaluation of ne..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Institute of Child Health and Human Development, Centers for Disease Control and Prevention, and Office of Global AIDS Coordinator. Funding from these institutions was not associated with a research grant but supported directly the scientific workshop from which this work was generated. The project was also supported in part with US federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and US Department of Department of Health and Human Services (contract HHSN272200800014C). D. S. and G. M. were supported by the International Maternal Pediatric Adolescent AIDS Clinical Trials Group Statistical and Data Management Center grant (grant No UM01 AI068616). L. E. C. was supported by a Thrasher Research Fund grant (contract 02824-6).