Journal article

Evaluation of Tuberculosis Diagnostics in Children: 2. Methodological Issues for Conducting and Reporting Research Evaluations of Tuberculosis Diagnostics for Intrathoracic Tuberculosis in Children. Consensus From an Expert Panel(a)

Luis E Cuevas, Renee Browning, Patrick Bossuyt, Martina Casenghi, Mark F Cotton, Andrea T Cruz, Lori E Dodd, Francis Drobniewski, Marianne Gale, Stephen M Graham, Malgosia Grzemska, Norbert Heinrich, Anneke C Hesseling, Robin Huebner, Patrick Jean-Philippe, Sushil Kumar Kabra, Beate Kampmann, Deborah Lewinsohn, Meijuan Li, Christian Lienhardt Show all

JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2012

Abstract

Confirming the diagnosis of childhood tuberculosis is a major challenge. However, research on childhood tuberculosis as it relates to better diagnostics is often neglected because of technical difficulties, such as the slow growth in culture, the difficulty of obtaining specimens, and the diverse and relatively nonspecific clinical presentation of tuberculosis in this age group. Researchers often use individually designed criteria for enrollment, diagnostic classifications, and reference standards, thereby hindering the interpretation and comparability of their findings. The development of standardized research approaches and definitions is therefore needed to strengthen the evaluation of ne..

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Grants

Awarded by US Department of Department of Health and Human Services


Awarded by International Maternal Pediatric Adolescent AIDS Clinical Trials Group Statistical and Data Management Center


Awarded by Thrasher Research Fund


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Funding Acknowledgements

This work was supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Institute of Child Health and Human Development, Centers for Disease Control and Prevention, and Office of Global AIDS Coordinator. Funding from these institutions was not associated with a research grant but supported directly the scientific workshop from which this work was generated. The project was also supported in part with US federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and US Department of Department of Health and Human Services (contract HHSN272200800014C). D. S. and G. M. were supported by the International Maternal Pediatric Adolescent AIDS Clinical Trials Group Statistical and Data Management Center grant (grant No UM01 AI068616). L. E. C. was supported by a Thrasher Research Fund grant (contract 02824-6).