Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer
Sherene Loi, Christos Sotiriou, Benjamin Haibe-Kains, Francoise Lallemand, Nelly M Conus, Martine J Piccart, Terence P Speed, Grant A McArthur
BMC MEDICAL GENOMICS | BMC | Published : 2009
BACKGROUND: Within estrogen receptor-positive breast cancer (ER+ BC), the expression levels of proliferation-related genes can define two clinically distinct molecular subtypes. When treated with adjuvant tamoxifen, those ER+ BCs that are lowly proliferative have a good prognosis (luminal-A subtype), however the clinical outcome of those that are highly proliferative is poor (luminal-B subtype). METHODS: To investigate the biological basis for these observations, gene set enrichment analysis (GSEA) was performed using microarray data from 246 ER+ BC samples from women treated with adjuvant tamoxifen monotherapy. To create an in vitro model of growth factor (GF) signaling activation, MCF-7 ce..View full abstract
Sherene Loi is supported by the American Society of Clinical Oncology (ASCO) Young Investigators's grant, the National Breast Cancer Foundation of Australia, the National Health and Medical Research Council of Australia and the Royal Australian College of Physicians'. Grant McArthur is the Weary Dunlop Cancer Research Fellow of the Cancer Council of Victoria. The authors thank Andrew Deans for helpful discussion. This work was supported by grants from the Cancer Council of Victoria, Australia. Christos Sotiriou is supported by the E. Lauder Breast Cancer Foundation, the MEDIC foundation and Belgian National Foundation for Research (FNRS). Benjamin Haibe-Kains is supported by the Belgian National Foundation for Cancer Research (FNRS).