Journal article
Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3γ via gastric STAT3 activation
KS Lee, A Kalantzis, CB Jackson, L O'Connor, N Murata-Kamiya, M Hatakeyama, LM Judd, AS Giraud, TR Menheniott
Plos One | Published : 2012
Abstract
Background: Most of what is known about the Helicobacter pylori (H. pylori) cytotoxin, CagA, pertains to a much-vaunted role as a determinant of gastric inflammation and cancer. Little attention has been devoted to potential roles of CagA in the majority of H. pylori infected individuals not showing oncogenic progression, particularly in relation to host tolerance. Regenerating islet-derived (REG)3γ encodes a secreted C-type lectin that exerts direct bactericidal activity against Gram-positive bacteria in the intestine. Here, we extend this paradigm of lectin-mediated innate immunity, showing that REG3γ expression is triggered by CagA in the H. pylori-infected stomach. Methodology/Principal ..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
This work was supported by the Victorian Government's Operational Infrastructure Support Program and by a project grant awarded by the Australian National Health and Medical Research Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.