A33 Antigen-Deficient Mice Have Defective Colonic Mucosal Repair
Prue M Pereira-Fantini, Louise M Judd, Anastasia Kalantzis, Anthony Peterson, Matthias Ernst, Joan K Heath, Andrew S Giraud
Inflammatory Bowel Diseases | OXFORD UNIV PRESS INC | Published : 2010
BACKGROUND: A33 antigen is a transmembrane protein expressed predominantly in normal intestinal epithelium and most colon cancers and cell lines. The function of A33 antigen is unclear, but indirect evidence indicates a role in cell adhesion, trafficking, and the gut immune response. The aim of this study was to determine the contribution made by A33 antigen in mediating colonic repair following colitis induction in the A33 antigen-deficient mutant mouse. METHODS: Colitis was induced by treatment with TNBS/ethanol. A33 antigen-deficient or wildtype mice were sacrificed at 0, 3, 7, and 14 days after colitis induction and morphological damage, mucosal proliferation, and inflammatory cell infil..View full abstract
Supported by grants from the National Health and Medical Research Council of Australia.