Journal article

Language lateralization correlates with verbal memory performance in children with focal epilepsy

Regula Everts, A Simon Harvey, Leasha Lillywhite, Jacquie Wrennall, David F Abbott, Linda Gonzalez, Michael Kean, Graeme D Jackson, Vicki Anderson

EPILEPSIA | WILEY | Published : 2010

Abstract

PURPOSE: Assessment of language dominance with functional magnetic resonance imaging (fMRI) and neuropsychological evaluation is often used prior to epilepsy surgery. This study explores whether language lateralization and cognitive performance are systematically related in young patients with focal epilepsy. METHODS: Language fMRI and neuropsychological data (language, visuospatial functions, and memory) of 40 patients (7-18 years of age) with unilateral, refractory focal epilepsy in temporal and/or frontal areas of the left (n = 23) or right hemisphere (n = 17) were analyzed. fMRI data of 18 healthy controls (7-18 years) served as a normative sample. A laterality index was computed to dete..

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