Virologically Suppressed HIV Patients Show Activation of NK Cells and Persistent Innate Immune Activation
Gregor F Lichtfuss, Wan-Jung Cheng, Yagmur Farsakoglu, Geza Paukovics, Reena Rajasuriar, Pushparaj Velayudham, Marit Kramski, Anna C Hearps, Paul U Cameron, Sharon R Lewin, Suzanne M Crowe, Anthony Jaworowski
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2012
FcRγ is an ITAM-containing adaptor required for CD16 signaling and function in NK cells. We have previously shown that NK cells from HIV patients receiving combination antiretroviral therapy (cART) have decreased FcRγ expression, but the factors causing this are unknown. We conducted a cross-sectional study of cART-naive viremic patients (ART(-)), virologically suppressed patients receiving cART (ART(+)), and HIV-uninfected controls. CD8(+) T cells were activated, as assessed by CD38(+)HLA-DR(+) expression, in ART(-) patients (p < 0.0001), which was significantly reduced in ART(+) patients (p = 0.0005). In contrast, CD38(+)HLA-DR(+) NK cells were elevated in ART(-) patients (p = 0.0001) but ..View full abstract
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Awarded by National Health and Medical Research Council
This work was supported in part by National Health and Medical Research Council Project Grant 543137. S. R. L. is supported by a National Health and Medical Research Council Practitioner Fellowship and by The Alfred Foundation. S. M. C. is supported by a National Health and Medical Research Council Principal Research Fellowship. The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program.