Journal article

Towards an understanding of cognitive function in Friedreich ataxia

Louise A Corben, Nellie Georgiou-Karistianis, Michael C Fahey, Elsdon Storey, Andrew Churchyard, Malcolm Horne, John L Bradshaw, Martin B Delatycki

BRAIN RESEARCH BULLETIN | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2006

Abstract

There is limited documentation regarding cognitive function in individuals with Friedreich ataxia (FRDA), possibly because FRDA is widely held to predominantly affect the spinal cord, peripheral sensory nerves and cerebellum and not to affect cognition. Traditionally, the cerebellum has been thought to coordinate voluntary movement and motor tone, posture and gait. However, recent studies have implicated the cerebellum in a range of cognitive functions including executive function, visuospatial organisation and memory. We review the available data on cognitive function and neuroimaging in FRDA and the role of the cerebellum in cognitive function. We conclude with recommendations for future r..

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