Transcriptional suppression of lipid-induced apoptosis in skeletal muscle in vivo

Abstract

Lipotoxicity occurs when fatty acid (FA) delivery exceeds the storage capacity of non‐adipose tissues, causing cell dysfunction and/or death by apoptosis. FA metabolites accumulate in skeletal muscle (SM) in obesity and cause lipid‐induced apoptosis in vitro . AIM: To determine the lipotoxic effects of FAs in SM in vivo . SM lipotoxicity was investigated in 3 models of FA oversupply: C57Bl/6 mice fed a high fat diet (HFD) for 12 weeks, genetically obese ob/ob ..