Journal article
Phenotype and polyp landscape in serrated polyposis syndrome: A series of 100 patients from genetics clinics
C Rosty, DD Buchanan, MD Walsh, SA Pearson, E Pavluk, RJ Walters, M Clendenning, KJ Spring, MA Jenkins, AK Win, JL Hopper, K Sweet, WL Frankel, M Aronson, S Gallinger, J Goldblatt, S Woodall, J Arnold, NI Walker, JR Jass Show all
American Journal of Surgical Pathology | Published : 2012
Abstract
Serrated polyposis syndrome (SPS), also known as hyperplastic polyposis, is a syndrome of unknown genetic basis defined by the occurrence of multiple serrated polyps in the large intestine and associated with an increased risk of colorectal cancer (CRC). There are a variety of SPS presentations, which may encompass a continuum of phenotypes modified by environmental and genetic factors. To explore the phenotype of SPS, we recorded the histologic and molecular characteristics of multiple colorectal polyps in patients with SPS recruited between 2000 and 2010 from genetics clinics in Australia, New Zealand, Canada, and the United States. Three specialist gastrointestinal pathologists reviewed t..
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Awarded by National Cancer Institute
Funding Acknowledgements
Supported by grants from the Cancer Council Queensland, the National Health and Medical Research Council, and the National Cancer Institute 1R01CA123010 (Genetics of Serrated Neoplasia). J.P.Y. is a Cancer Council Queensland Senior Research Fellow. C.R. is the Jass Pathology Fellow (2010-2011).