Journal article

Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation

PR Ebeling, DM Thomas, B Erbas, JL Hopper, J Szer, AP Grigg

JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 1999

Abstract

A significant proportion of patients will be long-term survivors of bone marrow transplantation (BMT) and little is known about their risk of late bony complications. We therefore evaluated bone mineral density (BMD) prior to BMT, post-transplantation changes in BMD, and mechanisms of bone loss in long-term survivors. We performed two analyses. The first was a cross-sectional study of 83 consecutive BMT patients (38 F, 45 M), examining the relationship between BMD and bone turnover, measured immediately prior to transplantation, and a number of disease and patient variables. The second was a prospective study of 39 patients (19F, 20 M) followed for a median of 30 months (range 5-64 months) f..

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